2. Signaling Pathways
  3. Immunology/Inflammation
    Vitamin D Related/Nuclear Receptor
  4. Glucocorticoid Receptor

Glucocorticoid Receptor

Glucocorticoid Receptor

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Glucocorticoid Receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response. When the glucocorticoid receptor binds to glucocorticoids, its primary mechanism of action is the regulation of gene transcription. The unbound receptor resides in the cytosol of the cell. After the receptor is bound to glucocorticoid, the receptor-glucorticoid complex can take either of two paths. The activated GR complex up-regulates the expression of anti-inflammatory proteins in the nucleus or represses the expression of pro-inflammatory proteins in the cytosol by preventing the translocation of other transcription factors from the cytosol into the nucleus. Dexamethasone is an agonist, and RU486 and cyproterone acetate are antagonists of the GR. Also, progesterone and DHEA have antagonist effects on the GR.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B1540R
    Beclometasone (Standard)
    		Agonist
    Beclometasone (Standard) is the analytical standard of Beclometasone. This product is intended for research and analytical applications. Beclometasone (Beclomethasone) is a prototype glucocorticoid receptor agonist.
    Beclometasone (Standard)
  • HY-B0243R
    Meprednisone (Standard)
    		Agonist
    Meprednisone (Standard) is the analytical standard of Meprednisone. This product is intended for research and analytical applications. Meprednisone is a glucocorticoid and a methylated derivative of Prednisone (HY-B0214). Meprednisone modulates glucocorticoid receptor. Meprednisone is orally active.
    Meprednisone (Standard)
  • HY-13571AS
    Beclometasone dipropionate-d6
    		Agonist
    Beclometasone dipropionate-d6 is deuterium labeled Beclometasone dipropionate. Betamethasone dipropionate, the proagent of Betamethasone, is an orally active and potent glucocorticoid with anti-inflammatory and immunosuppressive activity. Betamethasone appears to be an effective inhibitor of LPS-induced inflammation and MMP release.
    Beclometasone dipropionate-d<sub>6</sub>
  • HY-19814
    Toripristone
    		Inhibitor
    Toripristone (RU-40555) is a cortisol receptor inhibitor. Toripristone combined with clarithromycin can increase the antibacterial activity of Mycobacterium avium complex infection.
    Toripristone
  • HY-W749404
    Clobetasone 17-Propionate
    		Activator
    Clobetasone propionate is a corticosteroid. Formulations containing clobetasol propionate have been used in the treatment of eczema, psoriasis, and lupus.
    Clobetasone 17-Propionate
  • HY-13570CS
    Betamethasone 21-phosphate-d5
    Betamethasone 21-phosphate-d5 is the deuterium labeled Betamethasone disodium phosphate. Betamethasone disodium phosphate (Betamethasone 21-phosphate disodium salt) is a kind of corticosteroid, which is commonly used in the intralesional research of keloids.
    Betamethasone 21-phosphate-d<sub>5</sub>
  • HY-B0248R
    Desonide (Standard)
    		Inhibitor
    Desonide (Standard) is the analytical standard of Desonide. This product is intended for research and analytical applications. Desonide is a non-fluorinated corticosteroid anti-inflammatory agent that acts on the glucocorticoid receptor. Desonide can also specifically bind to the mutant huntingtin protein (mHTT), reducing the level and toxicity of mHTT. Desonide can be used in the research of Huntington's disease and inflammatory diseases such as atopic dermatitis.
    Desonide (Standard)
  • HY-137197
    6β-Hydroxy dexamethasone
    		Control
    6β-Hydroxy dexamethasone is an active metabolite of the synthetic glucocorticoid Dexamethasone (HY-14648).
    6β-Hydroxy dexamethasone
  • HY-N14422
    Collismycin B
    		Inhibitor
    Collismycin B is a potent dexamethasone-glucocorticoid receptor inhibitor with an IC50 value of 10 µM. Collismycin B shows antimicrobial activity. Collismycin B shows cytotoxicity.
    Collismycin B
  • HY-B0214S1
    Prednisone-d7
    		Agonist
    Prednisone-d7 (Dehydrocortisone-d7) is deuterium labeled Prednisone. Prednisone (Adasone) is a corticosteroid agent with anti-inflammatory and immunosuppressive effects that can be used to study diseases related to systemic lupus erythematosus.
    Prednisone-d<sub>7</sub>
  • HY-B1365R
    Prednicarbate (Standard)
    		Agonist
    Prednicarbate (Standard) is the analytical standard of Prednicarbate. This product is intended for research and analytical applications. Prednicarbate is a topical corticosteroid agent. Prednicarbate can be used for the research of inflammatory skin diseases, such as atopic dermatitis.
    Prednicarbate (Standard)
  • HY-13570BR
    Betamethasone acetate (Standard)
    Betamethasone acetate (Standard) is the analytical standard of Betamethasone acetate. This product is intended for research and analytical applications. Betamethasone acetate is a glucocorticoid corticosteroid. Betamethasone acetate induces fetal lung maturation in preterm sheep.
    Betamethasone acetate (Standard)
  • HY-W740175
    6b-Hydroxy triamcinolone acetonide
    		Control
    6b-Hydroxy triamcinolone acetonide is a metabolite of the synthetic corticosteroid Triamcinolone acetonide (HY-B0636). 6b-Hydroxy triamcinolone acetonide is formed from triamcinolone acetonide by the cytochrome P450 (CYP) isoforms CYP3A4, CYP3A5, and CYP3A7.
    6b-Hydroxy triamcinolone acetonide
  • HY-13681S
    Methylprednisolone acetate-d6
    Methylprednisolone acetate-d6 is the deuterium labeled Methylprednisolone acetate (HY-13681). Methylprednisolone acetate, a prednisolone derivative, is a corticosteroid hormone. Methylprednisolone acetate can relieve pain and swelling that occurs with arthritis and other joint disorders in vivo.
    Methylprednisolone acetate-d<sub>6</sub>
  • HY-137919
    Fluticasone 17β-carboxylic acid
    		Control
    Fluticasone 17β-carboxylic acid is an intermediate in the synthesis of the glucocorticosteroid Fluticasone propionate (HY-B0154).
    Fluticasone 17β-carboxylic acid
  • HY-122213
    RU-25055
    		Antagonist
    RU-25055 is a potent antiglucocorticoid. RU-25055 inhibits early antigen production of the EpsteinBarr virus (EBV) by dexamethasone.
    RU-25055
  • HY-B1087R
    Prednisolone hemisuccinate (Standard)
    Prednisolone (hemisuccinate) (Standard) is the analytical standard of Prednisolone (hemisuccinate). This product is intended for research and analytical applications.
    Prednisolone hemisuccinate (Standard)
  • HY-B1616R
    Clobetasone butyrate (Standard)
    		Agonist
    Clobetasone butyrate (Standard) is the analytical standard of Clobetasone butyrate. This product is intended for research and analytical applications. Clobetasone butyrate is a synthetic glucocorticoid and has topical anti-inflammatory activity especially in skin. Clobetasone butyrate can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis and psoriasis.
    Clobetasone butyrate (Standard)
  • HY-106673R
    Hydrocortisone buteprate (Standard)
    Hydrocortisone buteprate (Standard) is the analytical standard of Hydrocortisone buteprate. This product is intended for research and analytical applications. Hydrocortisone buteprate (Hydrocortisone probutate) is a medium potent, non-halogenated double-ester of hydrocortisone with a favorable benefit/risk ratio for the treatment of inflammatory skin disorders. Hydrocortisone buteprate (Hydrocortisone probutate) is available as a 0.1% cream or ointment formulation.
    Hydrocortisone buteprate (Standard)
  • HY-B0154R
    Fluticasone (propionate) (Standard)
    		Agonist
    Fluticasone (propionate) (Standard) is the analytical standard of Fluticasone (propionate). This product is intended for research and analytical applications. Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity.
    Fluticasone (propionate) (Standard)
Cat. No. Product Name / Synonyms Application Reactivity